|
KMID : 1149220050130010009
|
|
Korean Journal of Oriental Medical Prescription
2005 Volume.13 No. 1 p.9 ~ p.33
|
|
|
Protective effect of injinhotang and its components on acetaminophen-induced hepatoxicity in rats
|
|
Choi Jae-Woo
Bae Chang-Wook
Park So-Young
Yun Hyun-Jeong
Park Sun-Dong
|
|
|
Abstract
|
|
|
|
Acetaminophen, which causes acute liver min in humans and animals, has made useful inducer of hepatoxicity for studying hepatopreventive drugs. Injinhotang is known as one of the hepatopreventive drugs. However, its mechanism of recovery of hepatoxicity treated with acetaminophen is poorly understood. this study was performed to observe the antioxidative effect of injinhotang extract and its several combination groups. The results were obtained as follows:1. In the study on free radical scavenging effect in vitro(the suppressing effect on peroxidation of linoleic acid on concentration, the scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system and the inhibitory effect on lipid peroxidation reaction by hydroxy radical in H2O2-Fe2+system, injinhotang have more effect than its components groups relatively. 2. In the study on antioxidants system in vivo(the level of serum LPO, the level of hepatic LPO, catalase, GSH, GST), only injnhotang has a significant effect. 3. In the study on hepatotoxicity(GOT, GPT,γ-GTP, ALP, LDH, b ilirubin), only injinhotang has a significant effect. These results suggest that injinhotang has the protective effect on acetaminophen-induced hepatoxicity. The mechanisms of these are supposed to be involved in antioxidant and three drugs’ cooperative synergy effect.
|
|
|
KEYWORD
|
|
|
injinhotang, acetaminophen, hepatoxicity
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|